Russian forces fired 60 missiles and carried out drone attacks across Ukraine on Friday, officials said, striking the capital Kyiv and cities in the north, south and west.
Two people were killed and five wounded when a residential building was hit in Kryvih Rih in central Ukraine.
Attacks have intensified this week as Russia targets Ukraine’s civilian infrastructure.
Power was completely down in Kharkiv in the north and several other regions.
Power was also out in the Sumy region close to Ukraine’s northern border with Russia, as well as the central cities of Poltava and Kremenchuk.
Ukraine has accused Russia of “weaponising winter” by striking essential facilities as temperatures plummet.
UN human rights commissioner Volker Turk warned on Thursday that further attacks on power facilities could “lead to a further serious deterioration in the humanitarian situation and spark more displacement”.
Kyiv Mayor Vitaliy Klitschko said three areas of the city were hit. Damage to energy infrastructure had affected water supplies and city metro lines were for the moment not running, he said.
The head of the regional administration, Oleksiy Kuleba, said Russia was “massively attacking Ukraine”.
Prime Minister Denys Shmyhal said this week that Russian strikes had damaged “all thermal and hydroelectric power plants”, leading to widespread blackouts and interruptions in heating and water supplies.
Fifteen rockets were reportedly fired at Zaporizhzhia in the south, while officials in the north-western Zhytomyr region said initial information suggested Russia had fired rockets and kamikaze drones at the same time.
Authorities say these attacks are Russia’s response to military setbacks on the battlefield, amid Ukraine’s recent successes in retaking occupied territory.